Dietary factors have long been known to play a major role in the development of obesity. The global increasing prevalence of obesity suggests that there should be some common changes in diet worldwide. In fact, a significant, yet, often neglected worldwide change in dietary factors in the past few decades is the food fortification-induced marked increase in the content of niacin. However, the effect of long-term exposure to excess niacin on human health remains to be unclear.
饮食因素被视为肥胖的一个重要因素。全球肥胖人数的激增显示可能全球范围内饮食因素有一些共同的改变。而事实上，一个标志性的改变在全世界过去的几十年中却都常常被无视，那就是强化营养的食物开始标示富含尼克酸。然而，长期使用尼克酸对人类健康的作用还是不明确的。
A research team from China examined the role of excess nicotinamide in glucose metabolism using co-loading of glucose and nicotinamide test. They proved that excess niacin intake-induced biphasic response, i.e., insulin resistance in the early phase and hypoglycemia in the late phase, may be a primary cause for the increased appetite in obesity.
一个来自中国的研究小组通过研究并行的葡萄糖与尼克酰胺的测试，调查了过度的尼克酰胺对糖代谢的影响，他们证实，过量的尼克酰胺可以诱发双重反应，像早起的胰岛素抵抗和晚期的低血糖反应，可能是一个肥胖症不断增加食欲的早期原因。
Their study will be published on May 21, 2010 in the World Journal of Gastroenterology.
他们的研究将在2010年5月21日在世界胃肠病学杂志上出版。
The study also revealed for the first time that the obesity prevalence among US children and adolescents increased in parallel with the increase of the per capita niacin consumption with a 10-year lag, in which niacin fortification-induced sharp increase in niacin contents in grain products may play a major role. Reducing niacin intake and facilitating niacin elimination through sweat-inducing physical activity may be a key factor in the prevention and treatment of obesity.
他们的研究也表明：美国儿童和成年人肥胖的流行的第一时间与每人尼克酰胺的消费量的增加有一个十年的延迟，这里强化食品中尼克酰胺用量的激增可能对肥胖的流行起重要的作用。减少尼克酰胺的摄入和通过体育锻炼来促进体内尼克酰胺的代谢将可能是一个阻止和治疗肥胖症的重要方法。
It seems that the long-term safety of niacin fortification needs to be carefully evaluated.
加用尼克酰胺的强化配方的长期安全性看来值得谨慎的评估。。。
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